2 edition of study of Kupffer cell function in liver transplantation found in the catalog.
study of Kupffer cell function in liver transplantation
Ian Laurence Russell Badger
Thesis (M.D) - University of Birmingham, Dept of Surgery, 1993.
|Statement||by Ian Laurence Russell Badger.|
BackgroundDietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response. AimsThe present study was to investigate the effect of lipid on Kupffer cells phenotype and function in vivo and in vitro. And further to investigate the impact of lipid on ability of Kupffer cell lipid antigen presentation to. Abstract. This study was conducted to compare the effects of day dietary exposure (2%) to low melt point paraffin wax (LMPW) on both general liver morphology and Kupffer cell (KC) function and morphology in female F and Sprague-Dawley (SD) by:
Hepatic macrophage (Kupffer cell) hyperplasia is often described in Wilson’s disease (WD). In many liver diseases, Kupffer cell activation is related to disease severity, liver function, and fibrosis but the importance in WD is unknown. Kupffer cell activation can be assessed by the P-concentration of soluble (s)CD, metabolic liver function by the galactose elimination capacity Cited by: 2. Thus modulation of Kupffer cell function before organ harvest could be beneficial in human liver transplantation and surgery. the cause of failure of liver grafts is complex and includes many factors involving organ retrieval, preservation, and by:
INTRODUCTION. Liver failure due to ischemia/reperfusion (I/R) injury is a serious problem during liver surgery ().Reperfusion injury represents an important cause of primary graft non-function during liver transplantation ().Microcirculatory derangement, energy depletion, and lipid peroxidation are associated with the development of I/R injury in the liver (). Harvesting trauma to the graft dramatically decreases survival after liver transplantation. Since activated Kupffer cells play a role in primary nonfunction, the purpose of this study was to test the hypothesis that organ manipulation activates Kupffer by:
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From a clinical perspective, Kupffer cells and monocyte-derived macrophages represent an exciting target in liver transplantation. The heterogeneous pool of hepatic macrophages balances tolerance versus rejection (with a clear importance of Kupffer cells for establishing long-term tolerance) as well as inflammation and anti-infective defense (with an important contribution of infiltrating monocyte-derived.
Kupffer cells (KC) play major roles in immunity and tissue injury or repair. Because recapitulation of KC biology and function within liver will allow superior insights into their functional repertoire, we studied the efficacy of the cell transplantation approach for this by: The liver consists essentially of two compartments, parenchymal cells (PC) and non parenchymal cells (NPC) i.
Kupffer cells, endothelial cells, fat storing cells and pit cells. PC remain after transplantation but NPC are eventually exchanged with host cells. Dynamic liver scintigraphy with albumin colloid, extracted by NPC, and IODIDA Cited by: 4.
Summary This chapter contains section titled: Morphological Characteristics and Localization of Kupffer Cells Functions of Kupffer Cells in the Liver Pathophysiological Role of Kupffer Cells References.
Kupffer cells (KCs), the resident macrophages of the liver, not only exert phagocytosis but also excrete proin-ﬂammatory cytokines. The role of KCs in immune re-sponse has been highlighted in early studies,9,10 yet its role in liver transplantation (LT) tolerance has been rarely reported It is noteworthy that tumor necrosisCited by: Owing to the different functions of Kupffer cells, they play an important role in liver diseases.
In this chapter, we review the role of Kupffer cells in infectious disease, fatty liver disease. Kupffer cells, the resident macrophages of the liver, play a major role in the pathogenesis of several diseases.
This unit contains an easy‐to‐follow procedure for effective isolation of liver Kupffer cells from rats and mice. The protocol provides viable Kupffer cells in Cited by: Toll‐like receptors (TLRs) are pathogen recognition receptors that orchestrate the innate immune response and the subsequent adaptive immune response.
TLRs can be triggered by exogenous ligands expressed by invading pathogens or by the release of endogenous ligands, such as that occurring through cellular injury during the transplantation process.
They are now recognized to play an important role in many facets of transplantation biology Cited by: A study published in the Journal of Molecular Medicine (). showed that Kupffer cells can control ion homeostasis through the exertion of regulatory signals for the expression of hepcidin.
Hepcidin is a peptide hormone that primarily controls the entry of iron in the circulatory system of mammals. Interestingly, when hepcidin levels increase (especially during an inflammation or an. Kupffer cells belong to the reticuloendothelial system in the liver, a highly dynamic and complex network, which constitutes a primary line of defense against invading microorganisms, functions Cited by: Kupffer cells (KC), the resident liver macrophages, are named after the pathologist C.
von Kupffer who apparently first recognized this non‐parencymal cell type. KC represent about 35% of the non‐parenchymal liver cells in normal adult mice.
They reside within the lumen of the liver sinusoids, adherent to the endothelial cells that compose the blood vessel by: Recently it is reported that Reticulon 4 B (Nogo-B) in Kupffer cells, which is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function, promoted M1 polarization, thereby accentuating liver injury in ALD in humans and mice, whereas absence of Nogo-B increased ER stress and M2 polarization in Kupffer cells (Park et al., ).Cited by: Kupffer cells reside within the lumen of liver sinusoids and phagocytose particulate matter such as apoptotic cellular debris and bacterial degradation products.
Based on their MHC class II restricted antigen presentation, they can function as antigen-presenting cells for CD4 + T-cells. INTRODUCTION. Kupffer cells are important in maintaining homeostasis and in host anti-tumor defense mechanism.
It is thought that Kupffer cells are resident macrophages in the liver and are one kind of the sinusoidal endothelial cells.Cited by: This study aimed to investigate the protective effects of ketamine against hepatic ischemia–reperfusion (I/R) injury by suppressing activation of Kupffer cells (KCs) in rat liver by: 1.
Role of Kupffer cells in the pathogenesis of liver disease Article Literature Review (PDF Available) in World Journal of Gastroenterology 12(46) January with Reads. Basic characteristics of liver regeneration.
Cell division is rarely seen in hepatocytes in the normal adult liver, as these cells are in the G0 phase of the cell cycle 3,r, after partial Cited by: History. The cells were first observed by Karl Wilhelm von Kupffer in The scientist called them "Sternzellen" (star cells or hepatic stellate cell) but thought, inaccurately, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it.
Inafter several years of research, Tadeusz Browicz identified them, correctly, as on: Macrophage. The purpose of this study was to determine whether prevention of Kupffer cell activation following orthotopic liver transplantation improves postoperative survival.
First, particle phagocytosis by Kupffer cells was monitored continuously from the uptake of colloidal carbon by the perfused by: Cell Stem Cell Review Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming Atsushi Miyajima, 1,* Minoru Tanaka,2,3 * and Tohru Itoh * 1Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, TokyoJapan.
However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, intrahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver .In the present study, Kupffer cells were demonstrated and Kupffer cells may function as an ‘amplification loop’ to enhance inflammation further in the liver.
Liver myofibro- transplantation and liver tissues of 3 patients with hepatic hemangioma as the normal controls. Compared with the normal.liver injury under conditions of BD to improve the outcome of liver transplantation.
As the resident macrophages in the liver, Kupffer cells (KCs) express key renin angiotensin system (RAS) compo - nents, and RAS activity potentially participates in pathology and .